Evan Gonzalez, DetroitStockCity.com

Events

Thu January 30 2020 • 12:05 PM — 1:00 PM
Seminar: “In Utero Exposures to E-cigarettes: implications for childhood obesity” with Stephania Cormier, PhD (Wiener Chair and Professor of Biological Sciences, Louisiana State University; Director, LSU Superfund Research Program; Professor of Comparative Biomedical Sciences, LSU School of Veterinary Medicine; Honorary Professor Child Health Research Centre, University of Queensland, Australia)
Location: Room SPH1 A1655, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed February 5 2020 • 12:00 PM — 1:00 PM
Seminar: with Kenneth Korach, PhD (Senior Investigator, Reproductive & Developmental Biology Laboratory / Receptor Biology Group, NIEHS)
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Thu February 20 2020 • 8:30 AM — 4:00 PM
Symposium: “From PBB to PFAS: Research and Action to Address Michigan’s Large Scale Chemical Contaminations”
Description: A symposium to facilitate community - researcher collaborations. Please check http://mleead.umich.edu/Event_FromPBBtoPFAS.php for information about registration and abstract submission.
Speakers:
  • Keynote: Linda S. Birnbaum, PhD, DABT, ATS Former Director, National Institute of Environmental Health Sciences and National Toxicology Program
  • Michele Marcus, PhD, Emory University
  • Jane Keon, Pine River Superfund Citizen Task Force
  • Francis Spaniola, former Michigan State Representative
  • Tony Spaniola, JD
  • Courtney Carignan, PhD, Michigan State University
  • More speakers and breakout sessions to be announced
Note: Please check back to register for this event. Due to limited space, registration will be required. This event will also be webcast, more details to follow.
Sponsored by: The University of Michigan M-LEEaD Center, Emory University’s HERCULES Center, and Central Michigan University
Location: Michigan League, 911 N. University, Ann Arbor, MI 48109-1265
Mon April 20 2020 • 12:00 PM — 12:55 PM
Seminar: with Rebecca Fry, PhD (Professor, Department of Environmental Sciences and Engineering, UNC Gillings School of Global Public Health; Associate Chair for Strategic Initiatives, Department of Environmental Sciences and Engineering Director of Graduate Studies, Curriculum in Toxicology; Research Professor, Department of Pediatrics Director, Institute for Environmental Health Solutions (IEHS))
Location: Room SPH1 A1655, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109

Previous Events

PLEASE NOTE: Many previous events are recorded and archived on our Multimedia page.

Fri December 6 2019 • 2:00 PM — 3:00 PM
Admin Core Seminar Series: “Lessons Learned for Developing an “Exposome” for Children’s Cohort Studies: Challenges and Successes in Applying new Methods for Assessment, Integration, and Analytics” with Elaine Faustman, PhD, Professor of Environmental and Occupational Health Sciences; Adjunct Professor of Public Policy & Governance; University of Washington
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue December 3 2019 • 12:00 PM — 12:50 PM
Environmental Research Seminar: “Statistics Online Computational Resource (SOCR) DataSifter: a statistical technique to protect research participant privacy while enabling data sharing” with Ivo D. Dinov, PhD, MS, Director, Statistics Online Computational Resource [SOCR], Professor of Health Behavior & Biological Sciences; and Computational Medicine & Bioinformatics
Description: Effective and pragmatic sharing of data that includes sensitive information is difficult. The validation and reproducibility of findings in many health, financial, intelligence, socioeconomic, and other high-dimensional case-studies is inhibited when the data can’t be shared and the results independently confirmed. Either the utility of the data may be compromised by significant masking of the data or alternatively there may be a high risk of exposing private personal or secure organizational information. Excessive scrambling or encoding of the information makes the information less useful for modeling, or analytical processing. Insufficient preprocessing may compromise sensitive information and introduce a substantial risk for re-identification of individuals by various stratification techniques.

To address this problem, the SOCR lab developed a novel statistical method (DataSifter) that provides on-the-fly obfuscation of high-dimensional structured and unstructured sensitive data, e.g., clinical data from electronic health records (EHR). This technique provides complete administrative control over the balance between risk of data re-identification and preservation of the data information. Under careful set up of user-defined privacy levels, our simulation experiments suggest that the DataSifter protects privacy while maintaining data utility for different types of outcomes of interest. The application of DataSifter on ABIDE data provides a realistic demonstration of how to employ the proposed algorithm on EHR with more than 500 features. We are extending the DataSifter to desensitize longitudinal data and free-text. Time-permitting, some additional SOCR tools and resources may be demonstrated (http://www.socr.umich.edu).
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue November 19 2019 • 12:00 PM — 12:50 PM
Environmental Research Seminar: “PFAS in MICHIGAN: the state of Michigan's investigations and response” with Betsy Wasilevich, PhD, MPH, Senior Epidemiologist, Michigan Dept of Health & Human Services
Description: Betsy Wasilevich (MDHHS) will present the Environmental Research seminar on “PFAS in MICHIGAN: the state of Michigan’s investigations and response”. Please join us as Dr. Wasilevich addresses the public health response efforts and how MDHHS has, and will continue to, investigate PFAS exposures and outcomes around the state.
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue October 29 2019 • 12:00 PM — 1:00 PM
Environmental Statistics Discussion: “57 varieties of regression, and some updates” with Rod Little, PhD, Richard D. Remington Distinguished University Professor of Biostatistics
Sponsored by: Integrated Health Sciences Core and Community Engagement Cores of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue October 22 2019 • 1:00 PM — 2:30 PM
Environmental Statistics Day: “Prediction Error and Model Evaluation for Space-Time Downscaling: Case Studies in Air Pollution during Wildfires” with Donatello Telesca, PhD., Assoc. Professor, Biostatistics, UCLA
Description: Public Health Scientists use prediction models to downscale (i.e., interpolate) air pollution exposure where monitoring data is insufficient. This exercise aims to obtain estimates at fine resolutions, so that exposure data may reliably be related to health outcomes. In this setting, substantial research efforts have been dedicated to the development of statistical models capable of integrating heterogenous information to obtain accurate prediction: statistical downscaling models, land use regression, as well as machine learning strategies. However, when presented with the tasks of choosing between models, or averaging models, we find that our understanding of model performance in the absence of independent statistical replications remains insufficient. This lecture is motivated by several studies of air pollution (PM 2.5 and ground-level ozone) during wildfires. We review the basis for cross validation as a strategy for the estimation of the expected prediction error. As these performance measure play a crucial role in model selection and averaging we present a formal characterization of the estimands targeted by different data subsetting strategies, and explore their performance in engineered data settings. A final analysis and a warning about preference inversion is presented in relation to a 2008 wildfire event in Northern California.

Dr. Telesca is Associate Professor of Biostatistics at the University of California Los Angeles. He received a Ph.D. in Statistics from the University of Washington and spent two years at the University of Texas M.D. Anderson Cancer Center as a postdoctoral fellow. His research interests include Bayesian methods in multivariate statistics, functional data analysis, statistical methods in bio- and nano-informatics. Dr. Telesca is a member of the California NanoSystems Institute, the UCLA Jonsson Comprehensive Cancer Center and principal data scientist at Lucid Circuit Inc.
Sponsored by: Integrated Health Sciences Core, Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) NIEHS grant P30ES017885
Location: Room SPH-I 1690, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Fri October 11 2019 • 2:00 PM — 3:00 PM
Fall Seminar Series: “The landscape of benign breast and breast cancer” with Melissa Troester, PhD, Professor, Department Of Epidemiology, UNC Gillings School of Global Public Health; Research Professor, Department Of Pathology And Laboratory Medicine
Description: Dr. Melissa Troester’s laboratory studies breast cancer and benign breast disease using genomic, molecular pathology, and epidemiologic approaches. Much of Dr. Troester’s research focus has been on understanding interactions between the environment and breast genomics.
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue October 8 2019 • 12:00 PM — 12:50 PM
Environmental Research Seminar: “Every Sector is Public Health Sector: Building Capacity to Address Environmental Health Inequities” with Natalie Sampson, PhD, Ass't Prof., Health & Human Services, U-M Dearborn
Description: Click here to read “How researchers can help win the long game on public health”, featuring Dr. Sampson’s research into public health issues in Detroit’s Delray neighborhood.
Sponsored by: Community Engagement Core (CEC) and Integrated Health Sciences Core (IHSC), Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed October 2 2019 • 12:00 PM — 1:00 PM
Environmental Research Seminar: “Health, Nature and Our Built Environment: Change through Radical Collaborations” with Jack Spengler PhD, Akira Yamaguchi Professor of Environmental Health & Human Habitation, Harvard T.H. Chan School of Public Health
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 2610, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue October 1 2019 • 12:00 PM — 12:50 PM
Environmental Research Seminar:
Description: Discussants will share their experiences with creating equitable partnerships between community members and academic researchers, and touch on some of the challenges. There will be time for Q&A too. Please join us for a stimulating discussion, and feel free to bring your lunch. Organized by the Community Engagement and Integrated Health Sciences Cores of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue September 10 2019 • 12:00 PM — 1:00 PM
Environmental Research Seminar: “Health & Household-Related Benefits of Weatherizing Low-Income Homes & Affordable Multifamily Buildings” with Bruce Tonn, PhD, Co-Founder and President, Three3, Inc/ThreeCubed
Sponsored by: the Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue July 23 2019 • 11:00 AM — 12:00 PM
Summer Omics Learning Seminar Series : “Genomics: The Michigan Genomics Initiative: An In-House Integrated Data Frame to Conduct Precision Health Queries” with Dr. Bhramar Mukherjee, University of Michigan
Description: Lunch will be provided after each seminar. Registration required. Please contact Katie Zarins (kmrents@umich.edu) with questions.
Sponsored by: M-LEEaD Omics and Bioinformatics Core and Department of Computational Medicine and Bioinformatics
Location: Palmer Commons: Forum Hall (4th Floor)
Tue July 9 2019 • 11:00 AM — 12:00 PM
Summer Omics Learning Seminar Series : “Adductomics: Strategies and approaches for human biomonitoring of environmental and dietary carcinogens” with Dr. Robert Turesky, University of Minnesota
Description: Lunch will be provided after each seminar. Registration required. Please contact Katie Zarins (kmrents@umich.edu) with questions.
Sponsored by: M-LEEaD Omics and Bioinformatics Core and Department of Computational Medicine and Bioinformatics
Location: Room SPH-I 1755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue June 18 2019 • 11:00 AM — 12:00 PM
Summer Omics Learning Seminar Series : “Metabolomics: Analyzing Metabolomics Data: Current Tools and Future Challenges” with Dr. Alla Karnovsky, University of Michigan
Description: Lunch will be provided after each seminar. Registration required. Please contact Katie Zarins (kmrents@umich.edu) with questions.
Sponsored by: M-LEEaD Omics and Bioinformatics Core and Department of Computational Medicine and Bioinformatics
Location: Room SPH-I 1655, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Thu May 23 2019 • 11:00 AM — 12:00 PM
Summer Omics Learning Seminar Series : “Transcriptomics: Learning mechanism of action from LINCS perturbation signatures” with Dr. Mario Medvedovic, University of Cincinnati
Description: Lunch will be provided after each seminar. Registration required. Please contact Katie Zarins (kmrents@umich.edu) with questions.
Sponsored by: M-LEEaD Omics and Bioinformatics Core and Department of Computational Medicine and Bioinformatics
Location: Room SPH-I 1755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed May 8 2019 • 11:00 AM — 12:00 PM
ICPSR Summer Program: “Translational Omics: Lessons Learned for Rigor and Reproducibility, Informed by the ‘Duke Case’” with Gilbert Omenn, M.D., Ph.D., Harold T. Shapiro Distinguished University Professor of Internal Medicine, Human Genetics, and Public Health
Location: Room G150, Perry Building, 330 Packard, Ann Arbor, Michigan
Tue May 7 2019 • 11:00 AM — 12:00 PM
ICPSR Summer Program: “The Michigan Genomics Initiative: Managing a Dynamic University Resource” with Matthew Zawistowski, Ph.D., Clinical Assistant Professor of Biostatistics
Location: Room G150, Perry Building, 330 Packard, Ann Arbor, Michigan
Tue April 16 2019 • 12:00 PM — 1:00 PM
Environmental Research Seminar: “Statistical Analysis of Mixtures and Large-Scale Exposure Data: Hopes, Hypes and Hypotheses” with Bhramar Mukherjee, PhD, Professor & Chair of Biostatistics; Professor of Epidemiology and Global Public Health
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue April 2 2019 • 12:00 PM — 1:00 PM
Environmental Research Seminar: “Exposed! Pathways from Normal to Extreme in Exposure Science” with Stuart Batterman, PhD, Professor, Environmental Health Sciences, UM SPH
Description: This seminar will discuss some of the techniques and issues in assessing exposure of both routine and extraordinary events in environmental and occupational settings.
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Thu March 28 2019 • 12:00 PM — 1:00 PM
Administrative Core Winter Seminar Series: “Placental-Maternal-Fetal Communication Vesicles and Pregnancy Health” with Yoel Sadovsky, MD , Executive Director, Magee-Womens Research Institute Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh
Location: Room 1655 SPH-I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Thu March 21 2019 • 11:30 AM — 1:00 PM
Policy Discussion: “From PBB to PFAS: Policy Lessons from Widespread Chemical Contaminations in Michigan”
Description: This event provided an opportunity for legislators and their staff to meet with environmental health researchers to discuss how Michigan can prevent and more effectively respond to future environmental contaminations.
Speakers: Michele Marcus, Professor, School of Public Health, Emory University, “Health effects of PBB Exposure in Michigan”; Edward Lorenz, Reid Knox Professor Emeritus, Alma College, “Important Lessons from the PBB Accident”; Al Franzblau, Professor of Environmental Health Sciences, University of Michigan, “PFAS: A Contemporary Environmental Contamination in Michigan”
Media:
For additional information about PBB and PFAS contaminations in Michigan visit:
Sponsored by: University of Michigan’s Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Center; Central Michigan University’s History Department Emory University’s Health and Exposome Research Center: Understanding Lifetime Exposures (HERCULES); Support for this event provided by the National Institute of Environmental Health Sciences, National Institutes of Health; Cosponsors: Senator Winnie Brinks, Senator Kevin Daley, Senator Peter MacGregor, Senator Sean McCann, Senator Rick Outman, Representative Abdullah Hammoud, Representative James Lower, and Representative Hank Vaupel
Location: Room 5550 Binsfeld Office Building, 201 Townsend St. Lansing, MI
Tue February 26 2019 • 3:30 PM — 5:00 PM
Environmental Practice Workshop: “Climate Change and Health: What the Science Says and What We Can Do”
Description: Registration closed. Please watch the recording here: https://www.youtube.com/watch?v=s9zCthg0G8M&t=3775.

Our climate is our planet’s life support system. Climate change influences human health and disease in numerous ways including impacts from increased extreme weather events, wildfire, decreased air quality, and illnesses transmitted by food, water, and diseases carriers such as mosquitoes and ticks. As described in the National Climate Assessment, some existing health threats will intensify and new health threats will emerge. Not everyone is equally at risk. Important considerations include age, economic resources, and location. Preventive and adaptive actions are urgently needed. Our panel of experts include authors of the National Climate Assessment Health and environmental sustainability and public health leaders.

Speakers:
• John Balbus, MD, MPH National Institute of Environmental Health Sciences;
• Kim Knowlton, DrPH Natural Resources Defense Council & Mailman School of Public Health, Columbia University
• welcoming remarks from F. DuBois Bowman, PhD, Dean, University of Michigan School of Public Health

Reception to follow.

Please go to http://mleead.umich.edu/Event_Climate_Change_and_Health_2019.php for more information.
Sponsored by: Michigan Lifestage Environmental Exposures and Disease Center (NIEHS funded); Co-Sponsors: School for Environment and Sustainability (SEAS); Department of Environmental Health Sciences, Michigan Public Health
Location: Palmer Commons, University of Michigan
Mon February 25 2019 • 4:30 PM — 6:00 PM
Administrative Core Winter Seminar Series:
Location: Room M1020 SPHII, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Mon February 25 2019 • 12:00 PM — 1:00 PM
Administrative Core Winter Seminar Series: “Role of environmental exposures in childhood obesity and cardiovascular risks, including assessment of economic cost burden” with Leonardo Trasande, MD, MPP , Associate Professor, Department of Pediatrics, Environmental Medicine, Population Health New York University
Location: Room SPH-I 3755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue February 19 2019 • 5:30 PM — 7:30 PM RESCHEDULED
Rescheduled from January 31
Film Screening: “The Devil We Know: the Chemistry of a Cover-Up”
Description: When a handful of West Virginia residents discover DuPont has been pumping its poisonous Teflon chemical into the air and public water supply of more than 70,000 people, they file one of the largest class action lawsuits in the history of environmental law. As the citizens of Parkersburg rise up against the forces that polluted their town, the story builds out to dozens of other American cities. In fact, as many as 110 million Americans may be drinking water tainted with PFAS chemicals. Exposure to this class of chemicals has even become a global phenomenon, spreading to places like Italy, the Netherlands, and China. For more, visit https://thedevilweknow.com/

All are welcome to attend this free screening. The film runs for an hour and a half and will be followed by a short Q&A panel with experts on PFAS. Pizza and beverages will be provided.

Please register at the following link so we know how much food to order (registration is free): https://www.eventbrite.com/e/the-devil-we-know-film-screening-tickets-56286816383
Sponsored by: Center for Occupational Health and Safety Engineering (COHSE) and Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: Room SPH-I 1755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue February 19 2019 • 12:00 PM — 1:00 PM
Environmental Statistics Discussion: “Design Matters: the Pros and Cons of Longitudinal versus Cross-Sectional Designs” with Thomas Braun, PhD, Professor of Biostatistics and Dentistry
Description: The Environmental Statistics Discussion series aims to increase statistical literacy by fostering discussion on statistical ideas and concepts that could be beneficial to non-statistically trained SPH researchers.

Two journal articles can be read to prepare for dialogue: Where science meets policy: comparing longitudinal and cross-sectional designs to address diarrhoeal disease burden in the developing world (Amanda R Markovitz) + Blood Lead Levels of Children in Flint, Michigan: 2006-2016 (Hernán F. Gómez, MD)
Sponsored by: Integrated Health Sciences Core of the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) funded by grant P30ES017885 from the National Institute of Environmental Health Sciences
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed February 13 2019 • 1:00 PM — 2:00 PM
Winter Seminar Series with ETEP Symposium: “Career Talk” with Gwen Collman, PhD , Director – Division of Extramural Research & Training National Institute of Environmental Health Sciences
Sponsored by: Environmental Toxicology and Epidemiology Program (ETEP) and Career Development Program
Location: Room SPH-I 1755, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed February 13 2019 • 11:00 AM — 12:00 PM
Winter Seminar Series with ETEP Symposium: “Exposure to water contaminants associated with unconventional oil and gas extraction affects the immune system” with Paige Lawrence, PhD , Chair, Department of Environmental Medicine Director, Environmental Health Science Center University of Rochester Medical Center
Sponsored by: Environmental Toxicology and Epidemiology Program (ETEP) and Career Development Program
Location: Room SPH2 M1152, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Wed February 13 2019 • 10:00 AM — 11:00 AM
Winter Seminar Series with ETEP Symposium: “Endocrine and the Developmental Effects of Chemicals Used in Natural Gas Extraction” with Susan Nagel, PhD , Obstetrics, Gynecology, and Women᾿s Health University of Missouri School of Medicine
Sponsored by: Environmental Toxicology and Epidemiology Program (ETEP) and Career Development Program
Location: Room SPH2 M1152, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue February 5 2019 • 12:00 PM — 1:00 PM
Environmental Research Seminar: “PFAS: Evidence of Residential Segregation and Non-Linear Dose-Responses” with Sung Kyun Park, MPH, ScD, Associate Professor, Epidemiology & Environmental Health Sciences, UM SPH
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) Integrated Health Sciences Core
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue January 29 2019 • 12:00 PM — 1:00 PM
Environmental Statistics Discussion: “Multiple Perspectives on Multiple Comparisons” with Roderick Little, PhD, Richard D. Remington Distinguished University; Professor of Biostatistics; Professor, Department of Statistics; Research Professor, Institute for Social Research; Senior Fellow, Michigan Society of Fellows
Description: The Environmental Statistics Discussion series aims to increase statistical literacy by fostering discussion on statistical ideas and concepts that could be beneficial to non-statistically trained SPH researchers.
Sponsored by: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Location: 3755 SPH I, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109
Tue January 22 2019 • 1:00 PM — 2:00 PM
Environmental Statistics Day: “Linking a dose-response model to observed infection to describe spatial-temporal patterns in a Q fever outbreak” with Lance Waller, PhD , Professor & Chair Dept Biostatistics & Bioinformatics Rollins School of Public Health, Emory University
Description: We explore a Netherlands outbreak of Q fever in 2009 by combining a human dose–response model with geostatistics to predict local probability of infection, associated probability of illness, and local effective exposures to Coxiella burnetii. We begin with the spatial distribution of 220 notified cases in the at–risk population. Next, we use the dose-response relationship (established via historical experiments) to convert the observed risk map into an estimated smooth spatial field of local dose. Based on the observed symptomatic cases, the dose–response model predicts a median of 611 asymptomatic infections (95% range 410 to 1,084), i.e., 2.78 (95% range 1.86 to 4.93) asymptomatic infections for each reported case. The estimated peak levels of exposure extend to the north–east from the point source with an increasing proportion of asymptomatic infections further from the source. Our work combines established methodology from model-based geostatistics and dose-response modeling providing a novel approach to study outbreaks. Such predictions (and associated uncertainties) are important for targeting interventions during an outbreak, estimating future disease burden, and planning public health response. Joint work with R. John Brooke, St. Jude Children’s Research Hospital, Memphis TN; Peter FM Teunis, Centre for Infectious Disease Control, RIVM, Bilthoven, the Netherlands; Mirjam EE Kretzschmar, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
Sponsored by: Integrated Health Sciences Core
Location: Room SPH-I 1690, School of Public Health; 1415 Washington Heights; Ann Arbor, MI 48109