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included in our M-LEEaD Newsletter

M-LEEaD's recent renewal submission of the P30 Center Grant involved the re-design of our Translational Research Teams with the goal of accelerating public health impacts of the teams' work and promoting opportunities for collaboration.

The last of these teams to be featured in our monthly newsletter is the Toxicological Mechanisms and Improving Health Outcomes Team. This team, led by Dr. Vasantha Padmanabhan and Dr. Laurie Svoboda, seeks to advance mechanistic toxicology research that will inform behavioral, nutritional, and pharmacologic interventions aimed at mitigating the effects of exposures in human populations. This objective is met through the use of in vitro cell and tissue organoid models, animal models including sheep and mice, analysis of clinical specimens, mining of public databases, and epidemiologic studies.

Dr. Svoboda, who contributes to the team both as a co-leader and researcher, said, "Our work helps to facilitate the translation of fundamental questions into health impacts. This is a big part of the Translational Research Framework that the NIEHS encourages." Svoboda's research involves partnering with the UM Frankel Cardiovascular Center to investigate sex-specific effects of toxicants on cardiac differentiation.

Findings from Svoboda's and other Research Team members' work is ultimately used to inform risk assessment and intervention validation, with the wider goal of influencing public health practice and individual behaviors. In the long term, hopes are that these influences lead to mitigation of harmful environmental exposures and improvement in clinical outcomes.
Thank You and Best Wishes to M-LEEaD's Research Assistant Brianna Siracuse!
Brianna has graduated with a Master of Public Health Degree in Environmental Health Sciences. She will be starting a new job with Breast Cancer Prevention Partners later this month, where she will be working to address environmental exposures linked to breast cancer. M-LEEaD is so appreciative of your dedication over the past two years - Congratulations and wishing you all the best! 
A recent study published by Sung Kyun Park, with contributions from additional M-LEEaD members Bhramar Mukherjee and Siobán Harlow, has gathered attention from several news outlets. The groundbreaking study found that high concentrations of PFAS are associated with increased risk of diabetes in midlife women, similar to the risks posed by cigarette smoking and being overweight. Read more about this amazing study in Michigan News, Endocrinology Network, Medscape, and Science Daily.
In a recent study, the BBC took 45 tap water samples from sites in England. 25 of the sample analyzed contained PFAS, and almost half of the samples exceeded the European Food Standards Agency tolerable limit of 2.2ng/l. Rita Loch-Caruso provided comment in an article covering these findings, saying, "We're finding health effects at lower and lower concentrations - in the single digits." Read the full article here.
A recent New York Times article laid out the timeline, symptoms, and what to expect during menopause. Siobán Harlow, women's midlife health expert, provided insightful comments to the article. Her recent research on racial disparities in menopausal timing was also discussed. Read the full story here.
M-LEEaD member Eva Feldman was recently featured on an episode of the Lancet Neurology's podcast, "In Conversation With...". She spoke about the latest advances in the genetics, risk factors, pathophysiology, therapeutic development, and the diagnosis and prognosis of ALS. Listen to the episode here.
DuBois Bowman was recently featured on an episode of UM SPH's podcast, "Ahead of the Curve," where he spoke with Helene Gayle, president of The Chicago Community Trust. Their conversation focused on leadership, the power of mentorship, the importance of storytelling, and how to develop effective partnerships. Listen here.
Congratulations to M-LEEaD members Sean Harris, Justin Colacino, Miatta Buxton, Rita Loch-Caruso, and Kelly Bakulski! Their paper, "A Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways," was recently selected by the NIEHS as a paper of the month. This paper sheds light onto the important issue of preterm birth disparities. Read more about the paper here.
A new study published in Environmental Research has uncovered an interesting relationship between exposure to pesticides among mothers and sleep patterns of their offspring. Using data from the ELEMENT Cohort, the study found that in utero exposure to chlorpyrifos, but not pyrethroids, was associated with longer sleep duration and later midpoint of sleep among adolescent offspring, but only among girls. Several M-LEEaD members contributed to this study, including Erica Jansen, John Meeker, Karen Peterson, and Deb Watkins. Read more about this exciting new research here.
      5/11/2022 - 4:00 PM - 5:00 PM - Zoom   
NIEHS EHSCC Early Stage Investigators Webinar Series

Marissa Baker, PhD
Assistant Professor, Environmental and Occupational Health Sciences
University of Washington School of Public Health
Michael Petriello, PhD
Assistant Professor, Institute of Environmental Health Sciences and Pharmacology
Wayne State University


UM Center for Midlife Science has announced that this year's 2022 MaryFran Sowers Memorial Symposium will feature the career of M-LEEaD member Siobán D. Harlow. This year's symposium will take place on Thursday, May 12th and Friday, May 13th at the University of Michigan School of Public Health. 

Registration is required and in-person attendance is limited. You may register to attend in person and virtually. Contact Meredith McGehee with any questions.

Date: Thursday, May 12, 2022; Friday, May 13, 2022
Time: Thurs 1:30-4:30 pm; Fri 11 am - 1 pm
Location: Thurs @ Room M1020, SPH II; Fri @ Room 1655, SPH I
Online Registration here
In-Person registration here
Mark your calendar for the Saltiel Life Sciences Symposium 2022. This annual symposium is sponsored by the University of Michigan Life Sciences Institute and is open to the public. This year's theme is Viral Pathogens: Us vs. Them. The symposium will be held in Kahn Auditorium in the Biomedical Science Research Building on Friday, May 13 rom 8:45am - 4:30pm. See the full list of speakers here.

Date: Friday, May 13, 2022
Time: 8:45 am - 4:30 pm
Location: Khan Auditorium in the Biomedical Science Research Building
All NIEHS EHSCC Community Engagement Core (CEC) stakeholders are invited to NIEHS' virtual CEC Community Forum on May 18, 2022 from 1 pm to 3 pm EST. This year's forum will highlight community partners who are on the frontlines addressing environmental and climate injustices and discuss how to advance anti-racism and environmental justice within environmental health research and education more broadly. The forum is free and open to Center leadership, CEC staff, NIEHS staff, and Center community partners. Register by May 13th to receive pre-workshop resources and materials. 

Date: Wednesday, May 18, 2022
Time: 1 - 3 pm EST
Online registration here
Join the Michigan Department of Environment, Great Lakes, and Energy (EGLE) and the US EPA for the annual Areas of Concern (AOC) Conference. This year's conference will be held May 24 - 26 at the VanDyk Mortgage Convention Center in downtown Muskegon, Michigan. The deadline to register is May 13, 2022.

Find additional information, a conference agenda, and registration details here.

Date: Tuesday, May 24 - Thursday, May 26, 2022
Location: VanDyk Mortgage Convention Center
Register here
Are you looking to gain new skills in epidemiology? The University of Michigan Summer Session in Epidemiology offers short intensive courses in epidemiology to provide a foundation for understanding the principles, methods, and practice of epidemiology. This session is designed for public health and healthcare professionals, researchers, and anyone else who wants to build a foundation in epidemiologic science.

The session will run from July 11 - July 29, 2022, with 3 one-week course sessions. Participants can register for all three weeks, or choose to register for individual weeks based on interest. Find more information on course offerings and registration here.

Date: July 11 - July 29, 2022
Info and registration can be found here
Join Mount Sinai's Institute for Exposomic Research on July 12-13, 2022 for the 2022 NYC Exposome Symposium! This year's theme is "Health Equity and the Exposome: Understanding the Hidden Ways Environment Drives Health." The symposium will focus on the role of exposomics in the context of health disparities research and implications for improving clinical care for communities of color. This year's symposium will be held in-person in New York City, with live stream options available. For more information, the symposium agenda, and registration, visit the website here.

Date: Tuesday, July 12 - Wednesday, July 13, 2022
Info and registration here
Registration is now open for Columbia Mailman School of Public Health's Environmental Justice Boot Camp. The theme for the boot camp is "Theory and Methods to Study Environmental Health Disparities." This is a two-day intensive course featuring seminars and applied analytical session on key concepts, exposure assessment techniques, epidemiologic methods, community engagement and health policy applications, and statistical analytic approaches for conducting effective and solution-driven environmental justice research. The boot camp will be offered virtually on August 15-16, 2022. See the website for more information.

Date: Monday, August 15 - Tuesday, August 16, 2022
Time: 10 am - ~5:00 pm EST
Register here
Stay up to date on the latest M-LEEaD happenings and events and join the conversation by following us on twitter.
The anticipated RFA will provide grants to foster research related to M-LEEaD's mission and/or the Strategic Plan of the National Institute of Environmental Health Sciences (NIEHS). The official RFA for these upcoming pilot grants is expected in the coming weeks, pending official renewal of the M-LEEaD P30 center grant.

More information on this upcoming opportunity is available here. Contact Pilot Program Director Dr. John Meeker,, and M-LEEaD Administrator Rose Branstrom,, with any questions.
NIEHS is participating in the Implementation Research to Reduce Noncommunicable Disease (NCD) Burden in Low- and Middle-Income Countries (LMICs) and Tribal Nations During Critical Life Stages and Key Transition Periods (R01 Clinical Trial Optional) PAR (PAR-22-132). Applications are due July 27, 2022 for implementation research focused on implementation of interventions for these categories and others: to prevent or mitigate environmental exposures in childhood that lead to NCDs; to reduce primary and/or secondary exposures to pesticides and other chemicals in rural and agricultural settings; to reduce environmental NCD risks that consider individual and structural level social determinants of health; to prevent or mitigate exposures in children, adolescents, young and older adults that are attributed to climate change.
Recent Publications citing M-LEEaD:

Park SK, Wang X, Ding N, Karvonen-Gutierrez CA, Calafat AM, Herman WH, Mukherjee B, Harlow SD. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women's Health Across the Nation (SWAN). Diabetologia. 2022 Apr 11. doi: 10.1007/s00125-022-05695-5. Epub ahead of print. PMID: 35399113.

Click here for a PDF with useful information about NIH Public Access Policy regarding citing the center grant.

Per NIH grants policy, all publications, press releases, and other documents relevant to research funded by the center must include a specific acknowledgement of support. For the EHS Core Center, this statement may read:

“Support for this research was provided by grant P30ES017885 from the National Institute of Environmental Health Sciences, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

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