04/24/2018- Noon - Room 3755 SPH I Bhramar Mukherjee, PhD & Roderick Little, PhD
"To Bayes or not to Bayes"
Integrated Health Sciences Core
Environmental Statistics Discussion Series
Dr. Lada Koneva
During her year as M-LEEaD Center Scientist, Dr. Lada Koneva had the opportunity to attend the Annual Meeting Society of Toxicology (SOT) in San Antonio, Texas on March 11-15, 2018 where she presented the results of the M-LEEaD Funded Pilot Project “Transcriptomic and epigenomic effects of cadmium exposure during normal breast stem cell differentiation” alongside Dr. Justin Colacino. At the SOT conference Dr. Koneva enrolled in the Continuing Education Program and attended the course: “NGS Based Technologies Enable Biomarker Development and Discovery in Toxicology”. Methods presented in the course were applicable to strategies used in the M-LEEaD Omics and Bioinformatics Core for generating comprehensive toxicologically-relevant information on molecular changes in cells and tissue including talks by Julia Cui from University of Washington “Long noncoding RNAs: a novel paradigm in toxicology” and by Brian Chorley from US Environmental Protection Agency “Next-Generation sequencing applications for microRNA biomarker discovery in toxicological studies” among many others. Dr. Koneva looks forward to utilizing these new techniques to compliment her current research.
Dr. Deborah Watkins
In her year as M-LEEaD Center Scientist, Dr. Deborah Watkins worked to expand her scientific knowledge in neurodevelopment and neuropsychological assessment methods in order to identify effects of endocrine disrupting chemicals on the developing central nervous system. Dr. Watkins completed a biopsychology course (PSYCH 430) on brain development that emphasizes the role of the environment, and worked with neuropsychologists to incorporate assessment methods into her research. This work has been presented at the annual International Society for Environmental Epidemiology conference and two manuscripts are currently in preparation. Dr. Watkins has also met with researchers from the M-LEEaD Omics and Bioinformatics Core to explore and learn new methods for integrating metabolomics analysis into her work, and contributed to a project evaluating relationships between in utero phthalate exposure and metabolomics biomarkers during peripuberty. Going forward, Dr. Watkins will continue work in this area, as well as continue to explore methods for addressing exposure to chemical mixtures during sensitive periods of development.
Registration due date:
June 18, 2018 – March 31, 2019
There has been a significant increase in the global burden of chronic kidney diseases of uncertain or non-traditional etiologies, primarily in agricultural communities. This condition has variously been referred to as chronic kidney disease of unknown (CKDu) or non-traditional etiology (CKDnt), chronic intersitital nephritis in agricultural communities (CINAC) and Mesoamerican nephropathy (MeN). Although the general presentation of this condition appears to be similar across affected regions, it remains unclear whether this condition represents one common disease or a syndrome of related ones that differ from affected region to region. A number of potential etiologies and pathophysiological mechanisms for this condition have been proposed, but significant debate exists regarding which factor(s) are the most important to the incidence and progression of chronic kidney diseases in these agricultural communities.
To bring together clinicians, basic scientists, epidemiologists, and public health officials to discuss the current gaps in knowledge and to develop a coordinated scientific research agenda leading to a better understanding of the causes and potential treatments of chronic kidney diseases in agricultural communities.
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The 14th Precision Medicine World Conference (PMWC) will take place at the University of Michigan on June 6-7, 2018. This conference coincides with University of Michigan’s launch of a new Precision Health research initiative that integrates U of M’s strengths in Medicine, Engineering, Pharmacy, and Public Health. This initiative combines biomedical expertise, big data, and the social sciences enabling a comprehensive approach to providing patients with tailored health solutions. To support the University of Michigan’s goal to bring together leading researchers from across the university and the country to springboard this new and exciting research initiative, PMWC and U-M have agreed that the campus is an optimal location for the next conference. This forum will showcase practical content that helps close the knowledge gap among different sectors, thereby catalyzing cross-functional fertilization and collaboration to benefit both University of Michigan and PMWC attendees. The program will feature innovative technologies, and analyze the success of already thriving initiatives and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advances in precision medicine and cutting-edge strategies and solutions that are fundamentally changing how patients are treated. This is reflected in the Program Theme: “Big Data in Action: Insights in the Clinic”.
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Click here for a PDF with useful information about NIH Public Access Policy regarding citing the center grant.
Per NIH grants policy, all publications, press releases, and other documents relevant to research funded by the center must include a specific acknowledgement of support. For the EHS Core Center, this statement may read:
“Support for this research was provided by grant P30ES017885 from the National Institute of Environmental Health Sciences, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”